Deterministic Versus Stochastic Cell Polarisation Through Wave-Pinning

Deterministic Versus Stochastic Cell Polarisation Through Wave-Pinning

Cell polarization is an important part of the response of eukaryotic cells to stimuli, and forms a primary step in cell motility, differentiation, and many cellular functions. Among the important biochemical players implicated in the onset of intracellular asymmetries that constitute the early phases of polarization are the Rho GTPases, such as Cdc42, Rac, and Rho, which present high active con...

Deterministic Versus Stochastic Explanations

Oxygen isotope data for a Pliocene interval from 3.6 to 2.8 million years ago show a mean increase (0.5 per mil) of benthic 6180 at about 3.2 million years ago, whereas planktic 6180 does not increase. This lack of covariance indicates that the event at 3.2 million years did not result in a permanent increase in the ice budget of either the Northern or the Southern Hemisphere. The history of co...

Stochastic versus Deterministic Approaches

Deterministic versus stochastic models for circadian rhythms.

Circadian rhythms which occur with a period close to 24 h in nearly all living organisms originate from the negative autoregulation of gene expression.Deterministic models based on genetic regulatory processes account for theoccurrence of circadian rhythms in constant environmental conditions (e.g.constant darkness), for entrainment of these rhythms by light-dark cycles, and for their phase-shi...

Stochastic and Deterministic Decision in Cell Fate

From bacteria to mammals, individual cells from an isogenic population are able to assume roles resulting in phenotypic heterogeneity. The mechanisms used to make these cell fate decisions range from highly deterministic to essentially random. This wide range of behaviour springs from the interplay of intracellular molecular kinetics, the topologies of underlying gene regulator networks, epigen...